Bigneat LABS hoods (Laboratory Automation Biological System) for live cell applications and bio-hazards.

JUL 23rd, 2014 Blog, Company Update

LABS biological safety enclosure satisfies the demanding protection levels required in processes involving live cells, which previously could only be provided by smaller Class II cabinets.

Background

Screening of large numbers of potential anti-cancer drugs is an example of a typical procedure in drug development and it has been helped by the design of a new generation of robots which can pipette 96 or 384 samples at one time.

For cell work, where there is a need for both operator and sample protection; the latest laboratory robotics systems have become too large to be contained within a standard sized Class II laminar flow hood. A larger hood providing the levels of protection needed for the process such as a LABS hood from Bigneat should be perfect for the job.

How it works

To providing the sterile conditions for protection of the robotics system down-flow air is HEPA filtered in the enclosure roof and this passes through air diffuser grilles to be dispersed evenly throughout the enclosure. For protecting the operator when access to enclosure interior is required, laboratory air (perfectly controlled to 0.4m/s) enters the lower door windows passing into the enclosure and into a profile grille around the enclosure’s work surface. At all times the enclosure is maintained at a negative pressure.

Finally the used air is exhausted via under-bench outlet/exhaust HEPA filtration unit back into the laboratory.

Comfort and convenience is paramount for the operator.

LABS enclosures have all round clear view into the interior and access to the work surface is provided through 12” (300mm) sliding windows at the front of the enclosure. Key for maintenance and loading is the flexibility built into the design which enables access to all four sides for access to the hood interior and the contained automation equipment for installation and maintenance.

Performance is to NSF Standard 49, Category B2.

LABS enclosures can be used with Class II biohazards.

The high performance airflow system is continuously monitored and automatically compensates for airflow changes by a ‘closed-loop’ feedback to ensure there is always maximum possible level of operator and process protection. Of paramount importance is that the system is built to meet the fundamental requirements of NSF Standard 49, Category B2. In the event of a fan failure a LABS hood will enter a safe mode and maintain negative pressure ensuring operator safety at all times.

Safety features include audible and visual alarm indication of low airflow and door open and fan failure warning.

Economics: how costs are kept to a minimum when purchasing a LABS Enclosure.

The LABS is a compact system, which is intended to be installed with minimum interruption to the laboratory. Building works are avoided as the components of the enclosure will all fit through a standard laboratory door and there is no need to install the system into existing ducting as it is completely free standing.

The design of the enclosure allowed for sufficient space for ancillary equipment such as the vacuum pump and under bench storage and shelving is provided when required. It is also fitted with large castors to allow it to be moved and located where necessary within the laboratory.

LABS provide bio-safety for operator and contained laboratory automation and are manufactured in a range of enclosure sizes.

Widths available (inches): 59, 71, 87, 103, 126.

Bigneat’s LABS enclosure has been designed following years of practical experience and is an example of Bigneat’s innovation in bio-safety enclosure design & technology. They offer a range of features and options to assist the work-flow in the fast moving pharmaceutical, life sciences and drug development laboratory.

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